The South Africa Government intends to initiate a process to build a series of six nuclear plants, which is expected to supply 9,600MW of additional power for the country.
The planned power facilities are likely to involve an investment ranging from ZAR400bn to ZAR1 trillion ($34bn-$84bn) by 2030.
The first unit among the planned facilities is expected to be operational by 2023.
The nation with the most advanced economy in Africa is presently struggling to meet its power requirements, reports Reuters.
Russia had signed a $10bn deal with the country in September last year to set up nuclear facilities.
Other international partners to assist the country with its atomic power constructions include France, China, the US and South Korea, who all have signed deals for nuclear cooperation.
Agence France-Presse (AFP) quoted South Africa Energy Minister Tina Joemat-Pettersson as saying: "We will commence with the actual nuclear procurement process in the second quarter of this financial year to select a strategic partner or partners in a competitive, fair, transparent and cost effective manner.
"We expect to present the outcome of this procurement process to cabinet by year end."
South Africa is home to the continent’s only nuclear power station, which is located near Cape Town.
The country will also take measures to restore its nuclear fuel cycle industry by developing domestic uranium enrichment and conversion plants and nuclear fuel production sites.